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FIGURE 5 In the context of tendon biology, HIF-1α expression is markedly elevated during the early phase of tendon injury, where it promotes angiogenic signaling and metabolic reprogramming to support repair in hypoxic zones (Millar et al., 2012)

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To test the effects of DT-109 on dyslipidemia, hyperglycemia, and HS simultaneously, we fed Apo −/− mice WD with oral administration of 1 mg/g/day DT-109 (36) or equivalent amounts of leucine, glycine, or H 2 O (Fig